Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing

• Published in: ACS nano Vol. 12; no. 3; pp. 2695 - 2707
• Main Authors: Yu, Qingqing, Han, Yiming, Wang, Xiaocheng, Qin, Chen, Zhai, Dong, Yi, Zhengfang, Chang, Jiang, Xiao, Yin, Wu, Chengtie
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.03.2018
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Cell Line, Tumor; Copper - chemistry; Copper - therapeutic use; Drug Carriers - chemistry; Drug Carriers - therapeutic use; Drug Delivery Systems; Hyperthermia, Induced - methods; Male; Melanoma - pathology; Melanoma - therapy; Mice, Inbred BALB C; Mice, Nude; Nanostructures - chemistry; Nanostructures - therapeutic use; Phototherapy - methods; Pyridones - administration & dosage; Pyridones - therapeutic use; Pyrimidinones - administration & dosage; Pyrimidinones - therapeutic use; Silicates - chemistry; Silicates - therapeutic use; Skin Neoplasms - pathology; Skin Neoplasms - therapy; Tissue Scaffolds - chemistry; tissue healing; melanoma; copper silicate; chemotherapy; photothermal therapy
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.7b08928

The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor-initiated tissue defects.