Metal-Free Regioselective Cross Dehydrogenative Coupling of Cyclic Ethers and Aryl Carbonyls

A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC) of aryl carbonyls with cyclic ethers has been developed. This method offers easy access to substituted α-arylated cyclic ethers with a high functional group tolerance in good to excellent yields. The re...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 84; no. 4; pp. 2039 - 2047
Main Authors Mane, Kishor D, Mukherjee, Anagh, Vanka, Kumar, Suryavanshi, Gurunath
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.02.2019
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIDATION
ANTIPROLIFERATIVE ACTIVITY
IN-VITRO
BENZENE
ARYLATION
KINASE
LIGNANS
INHIBITORS
SESAME SEED
DISCOVERY
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Summary:A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC) of aryl carbonyls with cyclic ethers has been developed. This method offers easy access to substituted α-arylated cyclic ethers with a high functional group tolerance in good to excellent yields. The regioselectivity of this CDC reaction was confirmed by density functional theory (DFT)-based calculations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b03048