Electroorganic chemistry. 82. .beta.-Amino acid esters from .alpha.-methoxycarbamates and ketene silyl acetals; cyclization to .beta.-lactams

beta -Lactams are some of the most important antibiotics, as exemplified by penicillins and cephalosporins, and hence preparation of new compounds containing a beta -lactam moiety has always attracted much attention. The authors report herein a new synthetic method of beta -lactams utilizing the rea...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 49; no. 6; pp. 1056 - 1059
Main Authors Shono, Tatsuya, Tsubata, Kenji, Okinaga, Nobuyuki
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.03.1984
Subjects
amino acid esters
antibiotics
beta -lactams
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Summary:beta -Lactams are some of the most important antibiotics, as exemplified by penicillins and cephalosporins, and hence preparation of new compounds containing a beta -lactam moiety has always attracted much attention. The authors report herein a new synthetic method of beta -lactams utilizing the reaction of alpha -methoxylated carbamates with ketene methyl trimethylsilyl acetals as the key reaction.
Bibliography:istex:2D1E895C070CAAC97036003D89BAE91928D883E5
ark:/67375/TPS-NK3S45T8-7
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00180a020