Total synthesis of amphoteronolide B and amphotericin B. 2. Total synthesis of amphoteronolide B

The efficient coupling of building blocks 4-8 by four aldehyde-phosphonate type condensation reactions and an esterification reaction leading to advanced intermediate keto phosphonate aldehyde 39 are reported. The intramolecular keto phosphonate-aldehyde condensation leading to heptaenone 3 and its...

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Published inJournal of the American Chemical Society Vol. 110; no. 14; pp. 4685 - 4696
Main Authors Nicolaou, Kyriacos C, Daines, R. A, Chakraborty, T. K, Ogawa, Y
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.07.1988
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Summary:The efficient coupling of building blocks 4-8 by four aldehyde-phosphonate type condensation reactions and an esterification reaction leading to advanced intermediate keto phosphonate aldehyde 39 are reported. The intramolecular keto phosphonate-aldehyde condensation leading to heptaenone 3 and its elaboration to amphoteronolide B (1) are also described.
Bibliography:istex:02F13BA38BCEB06FA98681B6C52EFF9786324BC9
ark:/67375/TPS-TMZLC9LK-Q
ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja00222a029