Synthesis of (MeAla)TANDEM, the bis(N-methylalanine) analog of des-N-tetramethyltriostin A

• Published in: Journal of organic chemistry Vol. 46; no. 17; pp. 3436 - 3440
• Main Authors: Dhaon, Madhup K, Olsen, Richard K
• Format: Journal Article
• Language: English
• Published: American Chemical Society 01.08.1981
• Subjects: peptide synthesis; triostin

(MeAla super(2), MeAla super(6))des-N)-Tetramethyltriostin A (3), an analogue of the bicyclic octadepsipeptide antibiotic triostin A (1), has been prepared. Analogue 3 is of interest in studies relating to the mode of binding of the triostin antibiotics to nucleic acids. The analogue contains N)-met...