Synthesis of (MeAla)TANDEM, the bis(N-methylalanine) analog of des-N-tetramethyltriostin A

(MeAla super(2), MeAla super(6))des-N)-Tetramethyltriostin A (3), an analogue of the bicyclic octadepsipeptide antibiotic triostin A (1), has been prepared. Analogue 3 is of interest in studies relating to the mode of binding of the triostin antibiotics to nucleic acids. The analogue contains N)-met...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 46; no. 17; pp. 3436 - 3440
Main Authors Dhaon, Madhup K, Olsen, Richard K
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.08.1981
Subjects
peptide synthesis
triostin
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Summary:(MeAla super(2), MeAla super(6))des-N)-Tetramethyltriostin A (3), an analogue of the bicyclic octadepsipeptide antibiotic triostin A (1), has been prepared. Analogue 3 is of interest in studies relating to the mode of binding of the triostin antibiotics to nucleic acids. The analogue contains N)-methyl-L-alanine units in place of the two normal L-alanines and lacks the four N)-methyl groups common to the two pair of cysteine and valine residues.
Bibliography:istex:6CD6ECB33EB62933BA53058B71ACE6646B1C5A7D
ark:/67375/TPS-6M3M20LB-2
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00330a010