Catalytic asymmetric synthesis of quarternary carbon centers. Palladium-catalyzed formation of either enantiomer of spirooxindoles and related spirocyclics using a single enantiomer of a chiral diphosphine ligand

The asymmetric synthesis of eight spirooxindoles and related spirocyclics from the corresponding aryl iodide by palladium catalyzed cyclizations in the presence of the diphosphine ligand (R)-(+)-BINAP is reported.

Saved in:
Bibliographic Details
Published inJournal of organic chemistry Vol. 57; no. 17; pp. 4571 - 4572
Main Authors Ashimori, Atsuyuki, Overman, Larry E
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.08.1992
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
CIS-DECALIN DERIVATIVES
TRANSITION-METAL COMPLEXES
HECK REACTION
ARYLATION
Nitrogen heterocycle
Palladium Complexes
Lactam
Organic ligand
Iodine Organic compounds
Spiran
Acetal
Asymmetric synthesis
Ditertiary phosphine
Bicyclic compound
Optical purity
Aromatic compound
Enone
Online AccessGet full text

Cover

More Information
Summary:The asymmetric synthesis of eight spirooxindoles and related spirocyclics from the corresponding aryl iodide by palladium catalyzed cyclizations in the presence of the diphosphine ligand (R)-(+)-BINAP is reported.
Bibliography:istex:B9ABA3DB4EB884833FB6103797380EDB169525F0
ark:/67375/TPS-Q1PF5WFZ-L
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00043a005