Two New Naphthoquinones with Antiviral Activity from Rhinacanthus nasutus

• Published in: Journal of natural products (Washington, D.C.) Vol. 59; no. 8; pp. 808 - 811
• Main Authors: Sendl, Anna, Chen, Jian Lu, Jolad, S. D, Stoddart, Cheryl, Rozhon, Edward, Kernan, Michael, Nanakorn, Weerachai, Balick, Michael
• Format: Journal Article
• Language: English
• Published: CINCINNATI American Chemical Society 01.08.1996; AMER SOC PHARMACOGNOSY; American Society of Pharmacognosy
• Subjects: ACANTHACEAE; ANTIVIRAL; ANTIVIRAL AGENTS; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Biological and medical sciences; CHEMICAL COMPOSITION; Chemical Fractionation; CHEMICAL STRUCTURE; Chemistry, Medicinal; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; CYTOMEGALOVIRUS; Cytomegalovirus - drug effects; DERIVATIVES; DRUG PLANTS; ESPECTROMETRIA; ESTRUCTURA QUIMICA; General pharmacology; HERPETOVIRIDAE; Humans; Lethal Dose 50; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Naphthoquinones - chemistry; Naphthoquinones - isolation & purification; Naphthoquinones - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Sciences; PLANTAS MEDICINALES; PLANTE MEDICINALE; Plants, Medicinal; QUINONAS; QUINONE; QUINONES; RHINACANTHIN C; RHINACANTHIN D; Science & Technology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; STRUCTURE CHIMIQUE; TAILANDIA; THAILAND; THAILANDE; VIRICIDAS; Thailand; Asia; Oxygen heterocycle; Betaherpesvirinae; Medicinal plant; Acanthaceae; Folk medicine; Dicotyledones; Angiospermae; Bicyclic compound; Antiviral; Cytomegalovirus; Aliphatic compound; Pharmacognosy; Herpesviridae; Quinone; Naphthoquinone derivatives; Dienic compound; Condensed benzenic compound; In vitro; Biological activity; Virus; Plant origin; Isolation; Above ground plant part; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np9601871

Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 μg/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.