Ni and NiO Nanoparticles Decorated Metal–Organic Framework Nanosheets: Facile Synthesis and High-Performance Nonenzymatic Glucose Detection in Human Serum

• Published in: ACS applied materials & interfaces Vol. 9; no. 27; pp. 22342 - 22349
• Main Authors: Shu, Yun, Yan, Yan, Chen, Jingyuan, Xu, Qin, Pang, Huan, Hu, Xiaoya
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.07.2017
• Subjects: Electrodes; Glucose; Humans; Hydrogen Peroxide; Metal-Organic Frameworks; Nanoparticles; Nickel; Reproducibility of Results; glucose; electrocatalytic activity; Ni-MOF/Ni/NiO/C nanocomposite; human serum
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.7b07501

Ni-MOF (metal–organic framework)/Ni/NiO/carbon frame nanocomposite was formed by combing Ni and NiO nanoparticles and a C frame with Ni-MOF using an efficient one-step calcination method. The morphology and structure of Ni-MOF/Ni/NiO/C nanocomposite were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and energy disperse spectroscopy (EDS) mapping. Ni-MOF/Ni/NiO/C nanocomposites were immobilized onto glassy carbon electrodes (GCEs) with Nafion film to construct high-performance nonenzymatic glucose and H2O2 electrochemical sensors. Cyclic voltammetric (CV) study showed Ni-MOF/Ni/NiO/C nanocomposite displayed better electrocatalytic activity toward glucose oxidation as compared to Ni-MOF. Amperometric study indicated the glucose sensor displayed high performance, offering a low detection limit (0.8 μM), a high sensitivity of 367.45 mA M–1 cm–2, and a wide linear range (from 4 to 5664 μM). Importantly, good reproducibility, long-time stability, and excellent selectivity were obtained within the as-fabricated glucose sensor. Furthermore, the constructed high-performance sensor was utilized to monitor the glucose levels in human serum, and satisfactory results were obtained. It demonstrated the Ni-MOF/Ni/NiO/C nanocomposite can be used as a good electrochemical sensing material in practical biological applications.