Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

• Published in: ACS infectious diseases Vol. 10; no. 5; pp. 1483 - 1519
• Main Authors: Ralhan, Krittika, Iyer, Kavita A., Diaz, Leilani Lotti, Bird, Robert, Maind, Ankush, Zhou, Qiongqiong Angela
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.05.2024
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; Drug Resistance, Bacterial; Humans; Review; multidrug resistance; antibacterial; bacterial infection; antimicrobial resistance; antibiotics
• ISSN: 2373-8227; 2373-8227
• DOI: 10.1021/acsinfecdis.4c00115

The development of effective antibacterial solutions has become paramount in maintaining global health in this era of increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role in combating bacterial infections throughout history. However, the emergence of novel resistant strains necessitates constant innovation in antibacterial research. We have analyzed the data on antibacterials from the CAS Content Collection, the largest human-curated collection of published scientific knowledge, which has proven valuable for quantitative analysis of global scientific knowledge. Our analysis focuses on mining the CAS Content Collection data for recent publications (since 2012). This article aims to explore the intricate landscape of antibacterial research while reviewing the advancement from traditional antibiotics to novel and emerging antibacterial strategies. By delving into the resistance mechanisms, this paper highlights the need to find alternate strategies to address the growing concern.