(Hydroxymethyl)acylfulvene: An Illudin Derivative with Superior Antitumor Properties
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The primary allylic hydroxyl thus formed can undergo very facile replacement by a variety of nucleophiles. (Hydroxymethyl)acylfulvene (MGI.114) was more toxic than a precurso...
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Published in | Journal of natural products (Washington, D.C.) Vol. 59; no. 9; pp. 896 - 899 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
CINCINNATI
American Chemical Society
01.09.1996
AMER SOC PHARMACOGNOSY American Society of Pharmacognosy |
Subjects | |
Online Access | Get full text |
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Summary: | Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The primary allylic hydroxyl thus formed can undergo very facile replacement by a variety of nucleophiles. (Hydroxymethyl)acylfulvene (MGI.114) was more toxic than a precursor, acylfulvene, but less toxic than the parent compound illudin S to HL 60 cells. |
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Bibliography: | F60 9704167 Q60 istex:254922C38BEDD604F2D77C1B79F1990B7201A678 ark:/67375/TPS-DP2WHMHP-7 Abstract published in Advance ACS Abstracts, August 15, 1996. |
ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np960450y |