Detection, Structure and Function of Modified DNA Bases

While some DNA base modifications such as 5-methylcytosine have been known and studied for decades, recent discoveries of a number of other modified bases have stimulated research to understand their origin and function. Chemistry-based methods for their detection and analysis have proven to be impo...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 141; no. 16; pp. 6420 - 6429
Main Authors Hofer, Alexandre, Liu, Zheng J, Balasubramanian, Shankar
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 24.04.2019
Subjects
chemistry
nucleobases
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Summary:While some DNA base modifications such as 5-methylcytosine have been known and studied for decades, recent discoveries of a number of other modified bases have stimulated research to understand their origin and function. Chemistry-based methods for their detection and analysis have proven to be important for advancing the field. Here, we feature a selection of methods that have helped advance the field, along with some key advances in the understanding of how the chemistry of modified bases affects biological functions. We also discuss fundamental questions in the field that remain unanswered.
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ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.9b01915