Radioisotopic Assessment of Cerebral Edema

The brain antipyrine, red blood cell (RBC), albumin, and technetium spaces have been studied in the experimental animal. Control animal brains were compared with edematous brains, in which edema was induced either by water intoxication or triethyl tin. Both types of edema were characterized by a dec...

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Published inArchives of neurology (Chicago) Vol. 24; no. 4; pp. 287 - 290
Main Authors Potchen, E. James, Adatepe, Mustafa H, Studer, Rebecca, Penkoske, Michaele, Penkoske, Patricia, Perez, Carlos
Format Journal Article
LanguageEnglish
Published United States American Medical Association 01.04.1971
Subjects
Animals
Antipyrine
Brain Edema - chemically induced
Brain Edema - diagnosis
Erythrocytes
Female
Iodine Radioisotopes
Iron Isotopes
Methods
Radionuclide Imaging
Rats
Serum Albumin, Radio-Iodinated
Tin
Water Intoxication
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Summary:The brain antipyrine, red blood cell (RBC), albumin, and technetium spaces have been studied in the experimental animal. Control animal brains were compared with edematous brains, in which edema was induced either by water intoxication or triethyl tin. Both types of edema were characterized by a decrease in the RBC and albumin spaces. These observations and the ability to develop techniques with multiple isotopes suggest that it may be possible to recognize clinically and differentiate more subtle forms of brain swelling than is now possible with conventional brain scanning. KEY WORDS.— Cerebral edema; triethyltin edema; brain spaces; water intoxication.
ISSN:0003-9942
1538-3687
DOI:10.1001/archneur.1971.00480340019001