Ion-Selective Lipid Bilayers Tethered to Microcontact Printed Self-Assembled Monolayers Containing Cholesterol Derivatives

Microcontact printing has been used to prepare patterned self-assembled monolayers (SAMs) of cholesterylpolyethylenoxy thiol. These patterned SAMs were used as supports for the formation of integral supported lipid bilayers. Biofunctionality was confirmed by addition of valinomycin ionophores and gr...

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Bibliographic Details
Published inLangmuir Vol. 14; no. 17; pp. 4675 - 4678
Main Authors Jenkins, A. Toby A, Bushby, Richard J, Boden, Neville, Evans, Stephen D, Knowles, Peter F, Liu, Quanying, Miles, Robert E, Ogier, Simon D
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 18.08.1998
Subjects
Analytical chemistry
Biological and medical sciences
Biosensors
Biotechnology
Chemistry
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General, instrumentation
In solution. Condensed state. Thin layers
Methods. Procedures. Technologies
Molecular biophysics
Physico-chemical properties of biomolecules
Various methods and equipments
Printing
Self assembly
Monolayer
Biosensor
Immobilization
Lipids
Bilayer
Cholesterol
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Summary:Microcontact printing has been used to prepare patterned self-assembled monolayers (SAMs) of cholesterylpolyethylenoxy thiol. These patterned SAMs were used as supports for the formation of integral supported lipid bilayers. Biofunctionality was confirmed by addition of valinomycin ionophores and gramicidin ion channels. Impedance spectroscopy of the resulting bilayer structures, incorporating valinomycin and the gramicidin, showed the expected ion selectivity.
Bibliography:ark:/67375/TPS-B0MG09DT-4
istex:07DEEC302B59BCF6BE35C05B30A628B4D3456BEE
ISSN:0743-7463
1520-5827
DOI:10.1021/la980581u