Analysis of a Reactive Dimethylenedihydrothiophene in Methylene Chloride by Low-Temperature Atmospheric Pressure Ionization Mass Spectrometry

• Published in: Analytical chemistry (Washington) Vol. 68; no. 6; pp. 1062 - 1066
• Main Authors: Shiea, Jentaie, Wang, Wen-Shyang, Wang, Chin-Hsiung, Chen, Ping-Shu, Chou, Chin-Hsing
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15.03.1996
• Subjects: Analytical chemistry; Chemistry; Exact sciences and technology; Spectrometric and optical methods; Volatile compound; Sulfur heterocycle; Chemical analysis; Analysis method; Cooling; Atmospheric pressure; Chemical reactivity; Mass spectrometry; Electrospray; Quadrupole spectrometer; Low temperature; Organic compounds
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/ac951037i

The use of atmospheric pressure ionization at −78 °C for the analysis of a thermally unstable compound, 2,5-dimethylene-2,5-dihydrothiophene, dissolved in methylene chloride is demonstrated with a home-built low-temperature electrospray source connected to a quadruple mass analyzer. To prevent the analyte molecule from polymerizing at elevated temperatures, the sample solution was maintained at −78 °C in the dry-ice-cooled sample injection and sample loop units. The solution was delivered to the spray needle by compressing the nitrogen gas in a syringe which was connected to the sample loop by a Teflon tube. At such low temperature, a strong ion signal was obtained from the analyte molecule as a result of corona discharge ionization.