A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis

A new class of bacterial protein sensors monitors intracellular levels of -adenosylmethionine to modulate cell morphology, chemotaxis, and biofilm formation. Simultaneous regulation of these behaviors enables bacterial pathogens to survive within their niche. This sensor, exemplified by CheWS, is an...

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Published inmBio Vol. 14; no. 5; p. e0159823
Main Authors Muok, A R, Kurniyati, K, Cassidy, C K, Olsthoorn, F A, Ortega, D R, Mabrouk, A Sidi, Li, C, Briegel, A
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 31.10.2023
Subjects
biofilms
chemotaxis
cryoEM
Molecular and Cellular Biology
protein sensor
Research Article
cryoEM
protein sensor
biofilms
chemotaxis
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Summary:A new class of bacterial protein sensors monitors intracellular levels of -adenosylmethionine to modulate cell morphology, chemotaxis, and biofilm formation. Simultaneous regulation of these behaviors enables bacterial pathogens to survive within their niche. This sensor, exemplified by CheWS, is anchored to the chemotaxis array and its sensor domain is located below the chemotaxis rings. This position may allow the sensor to directly interact with the chemotaxis histidine kinase CheA. Collectively, these data establish a critical role of CheWS in pathogenesis and further illustrate the impact of studying non-canonical chemotaxis proteins.
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ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.01598-23