Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

Remarkable progress in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade. This enantioselective transformation now allows the use of these challenging reactive nucleophiles for the formation of chiral alcohols using catalytic amounts of chira...

Full description

Saved in:
Bibliographic Details
Published inACS catalysis Vol. 6; no. 3; pp. 1952 - 1970
Main Authors Collados, Juan F, Solà, Ricard, Harutyunyan, Syuzanna R, Maciá, Beatriz
Format Journal Article
LanguageEnglish
Published American Chemical Society 04.03.2016
Subjects
Grignard reagents
copper
1,2-addition reaction
carbonyl compound
titanium
enantioselective catalysis
Online AccessGet full text

Cover

More Information
Summary:Remarkable progress in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade. This enantioselective transformation now allows the use of these challenging reactive nucleophiles for the formation of chiral alcohols using catalytic amounts of chiral ligands. This review summarizes the developments in this area.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.5b02832