Antibacterial Mesoporous Silica Granules Containing a Stable N‑Halamine Moiety

• Published in: ACS omega Vol. 8; no. 24; pp. 21410 - 21417
• Main Authors: Shi, Yuqing, Xu, Haidong, He, Yijing, Tang, Xuan, Tian, Hongru, Liang, Jie
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.06.2023
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.2c04079

High-efficacy and regenerable antimicrobial silica granules were prepared via oxa-Michael addition between poly­(vinyl alcohol) (PVA) and methylene-bis-acrylamide (MBA) under the catalysis of sodium carbonate in an aqueous solution. Diluted water glass was added, and the solution pH was adjusted to about 7 to precipitate PVA-MBA modified mesoporous silica (PVA-MBA@SiO2) granules. N-Halamine-grafted silica (PVA-MBA-Cl@SiO2) granules were achieved by adding diluted sodium hypochlorite solution. It was found that a BET surface area of about 380 m2 g–1 for PVA-MBA@SiO2 granules and a Cl+% of about 3.80% for PVA-MBA-Cl@SiO2 granules could be achieved under optimized preparation conditions. Antimicrobial tests showed that the as-prepared antimicrobial silica granules were capable of about a 6-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 10 min of contact. Furthermore, the as-prepared antimicrobial silica granules can be recycled many times due to the excellent regenerability of their N-halamine functional groups and can be saved for a long time. With the above-mentioned advantages, the granules have potential applications in water disinfection.