Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significa...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 149; no. 11; p. 1592
Main Authors Renshaw, P F, Guimaraes, A R, Fava, M, Rosenbaum, J F, Pearlman, J D, Flood, J G, Puopolo, P R, Clancy, K, Gonzalez, R G
Format Journal Article
LanguageEnglish
Published United States 01.11.1992
Subjects
Adult
Brain - metabolism
Confidence Intervals
Depressive Disorder - blood
Depressive Disorder - drug therapy
Depressive Disorder - metabolism
Female
Fluorine
Fluoxetine - analogs & derivatives
Fluoxetine - blood
Fluoxetine - metabolism
Fluoxetine - therapeutic use
Humans
Magnetic Resonance Spectroscopy
Male
Obsessive-Compulsive Disorder - blood
Obsessive-Compulsive Disorder - drug therapy
Obsessive-Compulsive Disorder - metabolism
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Summary:In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD = 1.0) (95% confidence interval = 1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
ISSN:0002-953X
DOI:10.1176/ajp.149.11.1592