Calcium-Differentiated Cellular Internalization of Allosteric Framework Nucleic Acids for Targeted Payload Delivery

Target delivery systems have extensively shown promising applications in cancer therapy, and many of them function smartly by responding to the cancer cell microenvironment. Here, we for the first time report Ca2+-differentiated cellular internalization of 2D/3D framework nucleic acids (FNAs), enabl...

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Published inAnalytical chemistry (Washington) Vol. 94; no. 25; pp. 9097 - 9105
Main Authors Zheng, Jiao, Wang, Qiwei, Shi, Lin, Shi, Lili, Li, Tao
Format Journal Article
LanguageEnglish
Published Washington American Chemical Society 28.06.2022
Subjects
Allosteric properties
Analytical chemistry
Antisense therapy
calcium
Calcium ions
Cancer
cancer therapy
Cell surface
cellular microenvironment
Chemistry
Drug delivery
Drug delivery systems
drugs
Internalization
Medical treatment
Microenvironments
mRNA
neoplasm cells
Nucleic acids
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Summary:Target delivery systems have extensively shown promising applications in cancer therapy, and many of them function smartly by responding to the cancer cell microenvironment. Here, we for the first time report Ca2+-differentiated cellular internalization of 2D/3D framework nucleic acids (FNAs), enabling the engineering of a conceptually new target delivery system using an allosteric FNA nanovehicle. The FNA vehicle is subject to a 2D-to-3D transformation on the cancer cell surface via G-quadruplexes responding to environmental K+ and thereby allows its cell entry to be more efficiently promoted by Ca2+. This design enables the FNA vehicle to target cancer cells and selectively deliver an antisense strand-containing cargo for live-cell mRNA imaging. It would open new avenues toward targeted drug delivery and find extensive applications in precise disease treatment.
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ISSN:0003-2700
1520-6882
1520-6882
DOI:10.1021/acs.analchem.2c01434