Manganous Phosphate Acts as a Superoxide Dismutase

A substantial body of evidence indicates that high intracellular concentrations of inorganic manganous ions render some cells resistant to ionizing radiation and provide substantial antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes. We found that manganous phosphate...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 130; no. 14; pp. 4604 - 4606
Main Authors Barnese, Kevin, Gralla, Edith B, Cabelli, Diane E, Selverstone Valentine, Joan
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 09.04.2008
Subjects
Gamma Rays
Kinetics
Organometallic Compounds - chemistry
Pulse Radiolysis
Superoxide Dismutase - chemistry
Superoxides - chemistry
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Summary:A substantial body of evidence indicates that high intracellular concentrations of inorganic manganous ions render some cells resistant to ionizing radiation and provide substantial antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes. We found that manganous phosphate is unique among those manganous salts studied in its ability to remove superoxide rapidly and catalytically from aqueous solution via a disproportionation mechanism that is entirely different from those of the SOD enzymes.
Bibliography:istex:34D5F9E7261D0427521B060251544797A2D8F1CB
ark:/67375/TPS-6LX4XTJX-F
ObjectType-Article-1
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja710162n