Self-Duplicating Amplification in a Dynamic Combinatorial Library

A dynamic combinatorial library has been designed to produce a set of constituents among which one is able to self-complementarily direct its duplication. The overall molecular distribution in the library evolves along both kinetic and thermodynamic biases, leading to the amplification of the specie...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 130; no. 6; pp. 1826 - 1827
Main Authors Xu, Shengguang, Giuseppone, Nicolas
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.02.2008
Subjects
Chemical Sciences
Inorganic chemistry
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Summary:A dynamic combinatorial library has been designed to produce a set of constituents among which one is able to self-complementarily direct its duplication. The overall molecular distribution in the library evolves along both kinetic and thermodynamic biases, leading to the amplification of the species that reproduces most efficiently and to the depletion of the other competitors.
Bibliography:ark:/67375/TPS-ZLZXG6FM-2
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja710248q