An Electron-Conducting Cross-Linked Polyaniline-Based Redox Hydrogel, Formed in One Step at pH 7.2, Wires Glucose Oxidase

• Published in: Journal of the American Chemical Society Vol. 129; no. 22; pp. 7006 - 7007
• Main Authors: Mano, Nicolas, Yoo, Joung Eun, Tarver, Jacob, Loo, Yueh-Lin, Heller, Adam
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.06.2007
• Subjects: Aniline Compounds - chemistry; Catalysis; Chemical Sciences; Cross-Linking Reagents - chemistry; Electrochemistry - methods; Enzymes, Immobilized - chemistry; Enzymes, Immobilized - metabolism; Epoxy Resins - chemistry; Glucose - chemistry; Glucose - metabolism; Glucose Oxidase - chemistry; Glucose Oxidase - metabolism; Hydrogels - chemistry; Hydrogen-Ion Concentration; Oxidation-Reduction; Static Electricity
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja071946c

A polyaniline-based, electron-conducting, glucose-permeable, redox hydrogel was formed in one step at pH 7.2 by cross-linking polymer acid-templated polyaniline with a water-soluble diepoxide, poly(ethylene glycol diglycidyl ether). Coimmobilization of glucose oxidase in the hydrogel, by co-cross-linking in the same step, led to the electrical wiring of the enzyme and to the formation of a glucose electrooxidation catalyst, allowing the electrocatalytic oxidation of glucose at a steady-state current density of 225 μA·cm-2 at 0.3 V vs Ag/AgCl.