Supramolecular Assembly of DNA-Phenanthrene Conjugates into Vesicles with Light-Harvesting Properties

Vesicle-shaped supramolecular polymers are formed by self-assembly of a DNA duplex containing phenanthrene overhangs at both ends. In the presence of spermine, the phenanthrene overhangs act as sticky ends linking the DNA duplexes together. In aqueous solution, the assembly leads to vesicles with a...

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Bibliographic Details
Published inBioconjugate chemistry Vol. 29; no. 5; pp. 1505 - 1509
Main Authors Bösch, Caroline D, Jevric, Jovana, Bürki, Nutcha, Probst, Markus, Langenegger, Simon M, Häner, Robert
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 16.05.2018
Subjects
Base Sequence
Carbocyanines - chemistry
Chemical elements
Chemistry
Complementary DNA
Deoxyribonucleic acid
DNA
DNA - chemistry
Energy
Energy Transfer
Fluorescence
Functional groups
Light
Models, Molecular
Nanocapsules - chemistry
Nanocapsules - ultrastructure
Phenanthrene
Phenanthrenes - chemistry
Polymers
Pyrene
Pyrenes - chemistry
Self-assembly
Spermine
Supramolecular polymers
Vesicles
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Summary:Vesicle-shaped supramolecular polymers are formed by self-assembly of a DNA duplex containing phenanthrene overhangs at both ends. In the presence of spermine, the phenanthrene overhangs act as sticky ends linking the DNA duplexes together. In aqueous solution, the assembly leads to vesicles with a diameter in the range of 50–200 nm. Fluorescence measurements show that the assembled phenanthrene units act as light-harvesting complexes and transfer absorbed energy to an acceptor, such as pyrene or Cy3, which can either be directly added to the polymer or attached via a complementary DNA strand. The presence of DNA in the nanostructures allows the construction of light-harvesting vesicles that are amenable to derivatization with different functional groups.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.8b00263