Making “Sense” of DNA

Polarization-resolved vibrational sum frequency generation spectra of glass surfaces functionalized with single-stranded and duplex DNA oligonucleotides are presented. These spectra yield detailed conformational information of surface-bound oligonucleotides, including the chirality of the stereogeni...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 129; no. 24; pp. 7492 - 7493
Main Authors Stokes, Grace Y, Gibbs-Davis, Julianne M, Boman, Faith C, Stepp, Brian R, Condie, Allison G, Nguyen, SonBinh T, Geiger, Franz M
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 20.06.2007
Subjects
DNA - chemistry
Molecular Conformation
Nucleic Acid Conformation
Oligonucleotides - chemistry
Spectrophotometry
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Summary:Polarization-resolved vibrational sum frequency generation spectra of glass surfaces functionalized with single-stranded and duplex DNA oligonucleotides are presented. These spectra yield detailed conformational information of surface-bound oligonucleotides, including the chirality of the stereogenic centers and the chirality of the duplex structure.
Bibliography:ark:/67375/TPS-T4J35MRS-8
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja071848r