Mimicking pH-Gated Ionic Channels by Polyelectrolyte Complex Confinement Inside a Single Nanopore

Biological channels have served as inspiration to design stimuli-response artificial nanopores. Here we propose an original approach to design a pH-gate nanopore based on polyethylenimine and chondroitin-4-sulfate (ChS) layer-by-layer self-assembly. This approach is interesting because it is rapid a...

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Bibliographic Details
Published inLangmuir Vol. 33; no. 14; pp. 3484 - 3490
Main Authors Zhao, Yixuan, Janot, Jean-Marc, Balanzat, Emmanuel, Balme, Sébastien
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.04.2017
Subjects
Chemical Sciences
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Summary:Biological channels have served as inspiration to design stimuli-response artificial nanopores. Here we propose an original approach to design a pH-gate nanopore based on polyethylenimine and chondroitin-4-sulfate (ChS) layer-by-layer self-assembly. This approach is interesting because it is rapid and permits monitoring in real time of functionalization. The study of ionic transport through these single nanopores reveals a selectivity on anions and pH-gate properties at low salt concentration. It is open at pH below 4 or 5 depending on salt concentration. These properties are explained by the modification of both charge and conformation of ChS as well as swelling of the polyelectrolyte complex.
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ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.7b00377