Sulfonic Acid-Containing Flavonoids from the Roots of Phyllanthus acidus

Six new sulfonic acid-containing flavonoids, acidoflavanone (1), acidoauronol (2), 5-O-methylacidoauronol (3), acidoaurone (4), acidoisoflavone (5), and acidoflavonol (6), were isolated from the EtOH extract of the roots of Phyllanthus acidus. Their structures were unambiguously established by inter...

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Published inJournal of natural products (Washington, D.C.) Vol. 81; no. 9; pp. 2026 - 2031
Main Authors Duong, Thuc-Huy, Beniddir, Mehdi A, Nguyen, Van-Kieu, Aree, Thammarat, Gallard, Jean-François, Mac, Dinh-Hung, Nguyen, Huu-Hung, Bui, Xuan-Hao, Boustie, Joël, Nguyen, Kim-Phi-Phung, Chavasiri, Warinthorn, Le Pogam, Pierre
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 28.09.2018
Amer Chemical Soc
American Chemical Society
Subjects
Chemical Sciences
Chemistry, Medicinal
Flavonoids - analysis
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Pharmacology & Pharmacy
Phyllanthus - chemistry
Plant Extracts - analysis
Plant Roots - chemistry
Plant Sciences
Science & Technology
Sulfonic Acids - analysis
X-Ray Diffraction
GLYCOSIDES
SPECTROSCOPY
BIOASSAYS
PLANTS
SPECTRA
SKEELS
EUPHORBIACEAE
EXTRACT
CONSTITUENTS
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Summary:Six new sulfonic acid-containing flavonoids, acidoflavanone (1), acidoauronol (2), 5-O-methylacidoauronol (3), acidoaurone (4), acidoisoflavone (5), and acidoflavonol (6), were isolated from the EtOH extract of the roots of Phyllanthus acidus. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data, single-crystal X-ray diffraction analysis, and comparison to the literature data. These new structures represent the first examples of sulfonic acid-containing flavanones, auronols, aurones, and isoflavones.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.8b00322