Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 34; no. 1; pp. 463 - 466
Main Authors Roth, Bruce D, Bocan, Thomas M. A, Blankley, C. John, Chucholowski, Alexander W, Creger, Paul L, Creswell, Mark W, Ferguson, Erika, Newton, Roger S, O'Brien, Patrick
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 01.01.1991
Subjects
Animals
Anticholesteremic Agents - chemistry
Anticholesteremic Agents - pharmacology
Biological and medical sciences
General and cellular metabolism. Vitamins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Kinetics
Male
Medical sciences
Microsomes - enzymology
Microsomes, Liver - enzymology
Molecular Structure
Pharmacology. Drug treatments
Rats
Spleen - enzymology
Structure-Activity Relationship
Testis - enzymology
Tissue
Enzyme inhibitor
Hydroxymethylglutaryl-CoA reductase
Lipophily
Selectivity
Physicochemical properties activity relationship
Antilipemic agent
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More Information
Bibliography:ark:/67375/TPS-GM301BHK-B
istex:475DF02EF641584E58CA671DFD58F395D3A3B385
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00105a071