Preparation of Chiral Bromomethylenecyclopropane and Its Use in Suzuki–Miyaura Coupling: Synthesis of the Arylmethyl‑(Z)‑cyclopropane Structure Core

A preparative method for an optically active bromomethylenecyclopropane unit and its practical conversion to (Z)-cyclopropane-containing chiral compounds via Suzuki–Miyaura coupling were established.

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Bibliographic Details
Published inJournal of organic chemistry Vol. 78; no. 23; pp. 11714 - 11720
Main Authors Tanabe, Makoto, Watanabe, Mizuki, Hoshiya, Naoyuki, Mizuno, Akira, Fukuda, Hayato, Arisawa, Mitsuhiro, Shuto, Satoshi
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.12.2013
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Cyclopropanes - chemical synthesis
Cyclopropanes - chemistry
Hydrocarbons, Brominated - chemical synthesis
Hydrocarbons, Brominated - chemistry
Molecular Structure
Physical Sciences
Science & Technology
Stereoisomerism
CYCLOPROPANE RINGS
CONFORMATIONAL RESTRICTION
ANALOGS
METHYLENECYCLOPROPANES
RECEPTOR
HISTAMINE
DERIVATIVES
BINDING
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Summary:A preparative method for an optically active bromomethylenecyclopropane unit and its practical conversion to (Z)-cyclopropane-containing chiral compounds via Suzuki–Miyaura coupling were established.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo401675z