Methylpendolmycin, an Indolactam from a Nocardiopsis sp

Methylpendolmycin, a new indole alkaloid with an N-methylisoleucine moiety incorporated in the nine-membered indolactam ring, has been isolated from an actinomycete culture of Nocardiopsis. Methylpendolmycin exhibited inhibition of phorbol ester binding to protein kinase C. Its structure was assigne...

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 54; no. 5; pp. 1440 - 1443
Main Authors Sun, Hao H, White, Carole B, Dedinas, Jonas, Cooper, Raymond, Sedlock, David M
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 01.09.1991
Glendale, AZ American Society of Pharmacognosy
Subjects
Actinomycetales - chemistry
Alkaloids - chemistry
Alkaloids - isolation & purification
Analysis of complex biological substances
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Indoles - chemistry
Indoles - isolation & purification
Lactams - chemistry
Lactams - isolation & purification
Magnetic Resonance Spectroscopy
Molecular Structure
Plants and fungi
Actinomycetales
Alkaloid
Molecular structure
Nocardiopsis
Lactam
Plant origin
Bacteria
Nocardiaceae
Isolation
Actinomycetes
Extract
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Summary:Methylpendolmycin, a new indole alkaloid with an N-methylisoleucine moiety incorporated in the nine-membered indolactam ring, has been isolated from an actinomycete culture of Nocardiopsis. Methylpendolmycin exhibited inhibition of phorbol ester binding to protein kinase C. Its structure was assigned on the basis of spectroscopic data.
Bibliography:istex:158308935BF127DBB340D4D4A169B34DAF996703
ark:/67375/TPS-TWCTGJGF-1
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np50077a040