Coupling Reactions of Bromoalkynes with Imidazoles Mediated by Copper Salts: Synthesis of Novel N-Alkynylimidazoles
A cross-coupling reaction of imidazoles with bromoalkynes in the presence of a catalytic amount of CuI is reported. This protocol allows an access to novel N-(1-alkynyl)imidazoles in moderate to good yields.
Saved in:
Published in | Journal of organic chemistry Vol. 73; no. 16; pp. 6462 - 6465 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
15.08.2008
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A cross-coupling reaction of imidazoles with bromoalkynes in the presence of a catalytic amount of CuI is reported. This protocol allows an access to novel N-(1-alkynyl)imidazoles in moderate to good yields. |
---|---|
Bibliography: | ark:/67375/TPS-R4LQBGLX-G General procedure for bromoalkyne preparation, characterization data, and 1H NMR spectra for all new compounds. This material is available free of charge via the Internet at http://pubs.acs.org. istex:1969475E7650ABF0028C2F9B35D80026C59C9165 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/jo801118q |