Eukaryotic Microproteins

• Published in: Annual review of biochemistry Vol. 94; no. 1; pp. 1 - 28
• Main Authors: Jaunbocus, Nadiya, Ebenki, Valerie, Su, Haomiao, Slavoff, Sarah A
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 20.06.2025
• Subjects: Animals; Humans; Micropeptides; microprotein; Open Reading Frames; Peptides - chemistry; Peptides - genetics; Peptides - metabolism; Protein Biosynthesis; Ribosomes - genetics; Ribosomes - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; small open reading frame; smORF; small open reading frame; smORF; microprotein

Microproteins are polypeptides of 100–150 amino acids or fewer that have not been annotated by genome annotation consortia, given their small size and other noncanonical properties. Translated microproteins are now known to number in the thousands in the human genome, to function in critical cellula...