Unsaturation and Polar Head Effect on Gelation, Bioactive Release, and Cr/Cu Removal Ability of Glycolipids

Designing of multifunctional soft and smart materials from natural sources is a useful strategy for producing safer chemicals having potential applications in biomedical research and pharmaceutical industries. Herein, eight glycolipids with variation in unsaturation of hydrophobic tail and polar hea...

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Published inLangmuir Vol. 36; no. 12; pp. 3080 - 3088
Main Authors Sekhar, Kanaparedu P. C, Swain, Deepak Kumar, Holey, Snehal Ashokrao, Bojja, Sreedhar, Nayak, Rati Ranjan
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 31.03.2020
Subjects
bioactive compounds
biomedical research
chelation
chromium
cooking fats and oils
copper
curcumin
drugs
encapsulation
gelation
glycolipids
hydrogels
hydrophilicity
hydrophobicity
moieties
organogels
pharmaceutical industry
riboflavin
surfactants
thermal stability
water solubility
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Summary:Designing of multifunctional soft and smart materials from natural sources is a useful strategy for producing safer chemicals having potential applications in biomedical research and pharmaceutical industries. Herein, eight glycolipids with variation in unsaturation of hydrophobic tail and polar headgroup size were designed. The effect of unsaturation in the tail group and headgroup size on gelation ability, and mechanical and thermal stability of glycolipid hydro/organogels was studied to understand structure and property relationship. Glycolipids are functional amphiphilic molecules having potential applications in the field of drug delivery and metal removal. The encapsulation capacity and kinetic release behavior of hydrophobic/hydrophilic bioactives like curcumin/riboflavin from the hydrophobic/hydrophilic pockets of glycolipids hydro/organogels was examined. A significant observation was that the glucamine moiety of the glycolipid headgroup plays a vital role in removal of Cr and Cu from oil/water biphasic systems. Typical functions of the glycolipid hydrogels are metal chelation and enzyme-triggered release behavior, enabled them as promising material for Cr, Cu removal from edible oils and controlled release of water soluble/insoluble bioactives.
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ISSN:0743-7463
1520-5827
1520-5827
DOI:10.1021/acs.langmuir.0c00349