Medicinal Chemistry of hERG Optimizations:  Highlights and Hang-Ups

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 49; no. 17; pp. 5029 - 5046
Main Authors Jamieson, Craig, Moir, Elizabeth M, Rankovic, Zoran, Wishart, Grant
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 24.08.2006
Subjects
Animals
Binding Sites
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Drug toxicity and drugs side effects treatment
Ether-A-Go-Go Potassium Channels - antagonists & inhibitors
Ether-A-Go-Go Potassium Channels - chemistry
Ether-A-Go-Go Potassium Channels - physiology
Humans
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Potassium Channel Blockers - chemistry
Potassium Channel Blockers - pharmacology
Structure-Activity Relationship
Toxicity: cardiovascular system
Heart
Potassium channel antagonist
Toxicity
Dissociation constant
Zwitterion
Review
In vitro
Modeling
Optimization
In vivo
Structure activity relation
Classification
Molecular model
Property structure relationship
Chemical properties
Lipophilicity
Physicochemical properties
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Bibliography:istex:8B91E76B7BF6BF4622641C57FB0E2C54BD7A07D6
ark:/67375/TPS-BV0RZ2T3-H
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0022-2623
1520-4804
DOI:10.1021/jm060379l