Rhodium-Catalyzed Regioselective C–H Chlorination of 7‑Azaindoles Using 1,2-Dichloroethane

An unexpected rhodium-catalyzed regioselective C–H chlorination of 7-azaindoles was developed using 1,2-dichloroethane (DCE) as a chlorinating agent and 7-azaindole as the directing group. This protocol provides an efficient access to ortho-chlorinated azaindoles with operational simplicity, good fu...

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Published inOrganic letters Vol. 16; no. 20; pp. 5294 - 5297
Main Authors Qian, Guangyin, Hong, Xiaohu, Liu, Bingxin, Mao, Hong, Xu, Bin
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.10.2014
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
RECEPTOR ANTAGONISTS
ARYLATION
ISOCYANIDES
CYANATION
OXIDATIVE ANNULATION
BONDS EFFICIENT ACCESS
HALOGENATION
ALKYNES
SP
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Summary:An unexpected rhodium-catalyzed regioselective C–H chlorination of 7-azaindoles was developed using 1,2-dichloroethane (DCE) as a chlorinating agent and 7-azaindole as the directing group. This protocol provides an efficient access to ortho-chlorinated azaindoles with operational simplicity, good functional group tolerance, and a wide substrate scope.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol502447w