Molecular Reaction Mechanisms of Combination Treatments of Low-Dose Cisplatin with Radiotherapy and Photodynamic Therapy
Combination of low-dose cisplatin with radiotherapy or photodynamic therapy (PDT) is a novel cancer treatment. Using time-resolved femtosecond laser spectroscopy, we reveal the molecular mechanisms of the combinations of cisplatin with radiotherapy and PDT using indocyanine green (ICG) excited at 80...
Saved in:
Published in | Journal of medicinal chemistry Vol. 50; no. 11; pp. 2601 - 2604 |
---|---|
Main Author | |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Chemical Society
31.05.2007
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Combination of low-dose cisplatin with radiotherapy or photodynamic therapy (PDT) is a novel cancer treatment. Using time-resolved femtosecond laser spectroscopy, we reveal the molecular mechanisms of the combinations of cisplatin with radiotherapy and PDT using indocyanine green (ICG) excited at 800 nm. DNA damage measurements confirm that electron-transfer reactions of cisplatin with electrons generated in ionizing radiation and with the ICG singlet excited state in PDT are responsible for the cytotoxic enhancements. |
---|---|
Bibliography: | istex:B989CB441723B36CE41BDD3C3A8F3206EDD6B712 ark:/67375/TPS-3GTH4Z5M-N ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm061416b |