Molecular Reaction Mechanisms of Combination Treatments of Low-Dose Cisplatin with Radiotherapy and Photodynamic Therapy

• Published in: Journal of medicinal chemistry Vol. 50; no. 11; pp. 2601 - 2604
• Main Author: Lu, Q.-B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 31.05.2007
• Subjects: Antineoplastic agents; Antineoplastic Agents - chemistry; Biological and medical sciences; Cisplatin - chemistry; Combined Modality Therapy; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); DNA Damage; Electron Transport; Lasers; Medical sciences; Organic Chemicals - chemistry; Pharmacology. Drug treatments; Photochemotherapy; Photosensitizing Agents - chemistry; Radiotherapy; Spectrum Analysis - methods; Ultraviolet Rays; Antineoplastic agent; Divalent metal Complexes; Photodynamic therapy; Transition metal Complexes; Radiotherapy; Cisplatin; Alkylating agent; Chemotherapy; Treatment; DNA; Reaction mechanism; Combined treatment; Lesion; Platinum II Complexes
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm061416b

Combination of low-dose cisplatin with radiotherapy or photodynamic therapy (PDT) is a novel cancer treatment. Using time-resolved femtosecond laser spectroscopy, we reveal the molecular mechanisms of the combinations of cisplatin with radiotherapy and PDT using indocyanine green (ICG) excited at 800 nm. DNA damage measurements confirm that electron-transfer reactions of cisplatin with electrons generated in ionizing radiation and with the ICG singlet excited state in PDT are responsible for the cytotoxic enhancements.