“Click to Chelate”:  Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step

• Published in: Journal of the American Chemical Society Vol. 128; no. 47; pp. 15096 - 15097
• Main Authors: Mindt, Thomas L, Struthers, Harriet, Brans, Luc, Anguelov, Todor, Schweinsberg, Christian, Maes, Veronique, Tourwé, Dirk, Schibli, Roger
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 29.11.2006; Amer Chemical Soc
• Subjects: Alanine - analogs & derivatives; Alkynes - chemistry; Azides - chemistry; Chelating Agents - chemistry; Chemistry; Chemistry, Multidisciplinary; Exact sciences and technology; General and physical chemistry; Isotope Labeling - methods; Metals - chemistry; Peptides - chemistry; Physical Sciences; Science & Technology; Triazoles - chemical synthesis; Triazoles - chemistry; FUNCTIONALIZATION; TECHNETIUM; LIGANDS; HISTIDINE; AMINO-ACIDS; STRATEGY; COMPLEXES; SOLID-PHASE; CHEMISTRY; COORDINATION; Chemical synthesis; Chelates; Metal
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja066779f

Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The “click-to-chelate” approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications.