Asteltoxins from the Entomopathogenic Fungus Pochonia bulbillosa 8‑H-28

• Published in: Journal of natural products (Washington, D.C.) Vol. 78; no. 7; pp. 1730 - 1734
• Main Authors: Adachi, Hayamitsu, Doi, Hiroyasu, Kasahara, Yuichi, Sawa, Ryuichi, Nakajima, Kaori, Kubota, Yumiko, Hosokawa, Nobuo, Tateishi, Ken, Nomoto, Akio
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 24.07.2015; Amer Chemical Soc
• Subjects: Animals; Cell Survival - drug effects; Chemistry, Medicinal; Depsipeptides - pharmacology; Hypocreales - chemistry; Japan; Larva - drug effects; Life Sciences & Biomedicine; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacology & Pharmacy; Plant Sciences; Pyrones - chemistry; Pyrones - isolation & purification; Pyrones - pharmacology; Science & Technology; Spodoptera - drug effects; Japan; METABOLITES; AUROVERTIN-B; PYRONE; CARBONYL PHOTOCYCLOADDITION REACTION
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np500676j

New asteltoxins C (3) and D (4) were found in the extract of the entomopathogenic fungus Pochonia bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was isolated, and structural analysis led to a revision of the structure of asteltoxin B. Compounds 2 and 4 have a novel tricyclic ring system connected to a dienyl α-pyrone structure. Compound 3 has a 2,8-dioxabicyclo[3.3.0]­octane ring similar to that of asteltoxin (1). Compound 3 showed potent antiproliferative activity against NIAS-SL64 cells derived from the fat body of Spodoptera litura larvae, while 2 and 4 were inactive.