Ruthenium-Catalyzed Pyrrole Synthesis via Oxidative Annulation of Enamides and Alkynes

An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage of C(sp2)–H/N–H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering the reaction conditions slightly.

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Bibliographic Details
Published inOrganic letters Vol. 15; no. 1; pp. 136 - 139
Main Authors Li, Bin, Wang, Nuancheng, Liang, Yujie, Xu, Shansheng, Wang, Baiquan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 04.01.2013
Amer Chemical Soc
Subjects
Alkynes - chemistry
Amides - chemistry
Catalysis
Chemistry
Chemistry, Organic
Cyclization
Molecular Structure
Oxidation-Reduction
Physical Sciences
Pyrroles - chemical synthesis
Pyrroles - chemistry
Ruthenium - chemistry
Science & Technology
Stereoisomerism
H BOND ACTIVATION
FUNCTIONALIZATIONS
AMINES
SUBSTITUTED PYRROLES
IMINES
REGIOSELECTIVE SYNTHESIS
EFFICIENT SYNTHESIS
COPPER
CYCLIZATION
INDOLES
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Summary:An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage of C(sp2)–H/N–H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering the reaction conditions slightly.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303159h