Parallel Microflow Photochemistry: Process Optimization, Scale-up, and Library Synthesis

A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of sensitized photoadditions involving 2(5H)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthe...

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Bibliographic Details
Published inOrganic letters Vol. 14; no. 17; pp. 4342 - 4345
Main Authors Yavorskyy, Alexander, Shvydkiv, Oksana, Hoffmann, Norbert, Nolan, Kieran, Oelgemöller, Michael
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 07.09.2012
Subjects
Combinatorial Chemistry Techniques
Furans - chemical synthesis
Furans - chemistry
Molecular Structure
Photochemical Processes
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Summary:A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of sensitized photoadditions involving 2(5H)-furanones. The reactor allowed for rapid and energy-, time-, and space-efficient sensitizer screening, process optimization, validation, scale-up, and library synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol301773r