Studies on the Apoptotic Activity of Natural and Synthetic Retinoids:  Discovery of a New Class of Synthetic Terphenyls That Potently Support Cell Growth and Inhibit Apoptosis in Neuronal and HL-60 Cells

• Published in: Journal of medicinal chemistry Vol. 48; no. 13; pp. 4293 - 4299
• Main Authors: Simoni, Daniele, Giannini, Giuseppe, Roberti, Marinella, Rondanin, Riccardo, Baruchello, Riccardo, Rossi, Marcello, Grisolia, Giuseppina, Invidiata, Francesco Paolo, Aiello, Stefania, Marino, Silvia, Cavallini, Sabrina, Siniscalchi, Anna, Gebbia, Nicola, Crosta, Lucia, Grimaudo, Stefania, Abbadessa, Vincenzo, Di Cristina, Antonietta, Tolomeo, Manlio
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 30.06.2005; Amer Chemical Soc
• Subjects: Apoptosis - drug effects; Biological and medical sciences; Cell Division - drug effects; Chemistry, Medicinal; HL-60 Cells; Humans; Indicators and Reagents; Life Sciences & Biomedicine; Medical sciences; Miscellaneous; Neurons - cytology; Neurons - drug effects; Neurons - physiology; Neuropharmacology; Neuroprotective agent; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Retinoids - chemical synthesis; Retinoids - chemistry; Retinoids - pharmacology; Science & Technology; (14R)-14-HYDROXY-4,14-RETRO-RETINOL; RETINOBENZOIC ACIDS; BIPHENYL-4-CARBOXYLIC ACIDS; MULTIDRUG; DEATH; MECHANISMS; RECEPTOR-ALPHA; AROTINOIDS; Human; Cell proliferation; Ether; Leukemia; Benzene derivatives; Retinoid; Neuroprotective agent; In vitro; HL60 cell line; Position isomer; Cell line; Neuron; Cytoprotector; Structure activity relation; Cell death; Inhibition; Chemical synthesis; Tumor cell; Apoptosis
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm049080y

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.