Direct Oxidative Amidation of Aldehydes with Anilines under Mechanical Milling Conditions

• Published in: Journal of organic chemistry Vol. 73; no. 7; pp. 2955 - 2958
• Main Authors: Gao, Jie, Wang, Guan-Wu
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 04.04.2008; Amer Chemical Soc
• Subjects: Aldehydes - chemistry; Amides - chemical synthesis; Amides - chemistry; Aniline Compounds - chemistry; Chemistry; Chemistry, Organic; Exact sciences and technology; Friction; Magnesium Sulfate - chemistry; Molecular Structure; Motion; Noncondensed benzenic compounds; Organic chemistry; Oxidants - chemistry; Oxidation-Reduction; Physical Sciences; Preparations and properties; Science & Technology; Sulfuric Acids - chemistry; Temperature; ALCOHOLS; REARRANGEMENT; ASYMMETRIC-SYNTHESIS; CARBONYLATION; CATALYZED DOUBLE CARBOHYDROAMINATION; AMIDE SYNTHESIS; AMINES; ONE-POT; THIO ACIDS; BALL MILL; One pot reaction; Carboxamide; Benzenic compound; Aniline derivatives; Oxidation; Oxidant; Aldehyde; Amidation
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo800075t

Oxone is found to be an effective oxidant for the oxidative amidation of aldehydes with anilines to furnish amides in a one-pot process under mechanical milling conditions.