G-Quartet-Induced Nanoparticle Assembly

• Published in: Journal of the American Chemical Society Vol. 127; no. 33; pp. 11568 - 11569
• Main Authors: Li, Zhi, Mirkin, Chad A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 24.08.2005
• Subjects: Biological and medical sciences; Cross-disciplinary physics: materials science; rheology; Deoxyguanosine - chemistry; DNA - chemistry; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; G-Quadruplexes; Gold - chemistry; Interactions. Associations; Intermolecular phenomena; Materials science; Molecular biophysics; Nanoscale materials and structures: fabrication and characterization; Nanostructures - chemistry; Nanotubes; Nucleic Acid Conformation; Organometallic Compounds - chemistry; Physics; Surface Properties; Temperature; Thymine - chemistry; Transmission electron microscopy; Functionalization; Thermal transition; Molecular assembly; Molecular interaction; Molecular aggregation; Metal particle; Nanostructured materials; Ultraviolet visible spectrometry
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja053547s

The design and synthesis of a new class of gold nanoparticle with guanosine monophosphate derivatives or G-rich oligonucleotides as their surface ligands are described. These nanoparticles spontaneously form macroscopic assemblies at low temperature and relatively high salt concentrations, which is attributed to the cooperative formation of guanosine quartets and G-quadruplexes between the individual nanoparticles. Significantly, the solution behavior of these nanoparticles is highly controllable by adjusting solution parameters (including temperature, ionic strength, and ion species) and the sequence of the G-rich oligonucleotide