Self-Assembling a Molecular Pegboard

This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a “molecular pegboard”. We used th...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 127; no. 50; pp. 17606 - 17607
Main Authors Lund, Kyle, Liu, Yan, Lindsay, Stuart, Yan, Hao
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 21.12.2005
Subjects
Biological and medical sciences
DNA - chemical synthesis
DNA - chemistry
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Intermolecular phenomena
Microarray Analysis
Microscopy, Atomic Force
Models, Molecular
Molecular biophysics
Nanostructures - chemistry
Nucleic Acid Conformation
Nucleic Acid Hybridization
Streptavidin - chemistry
Molecular hybridization
Atomic force microscopy
Molecular assembly
Molecular association
Molecular interaction
Molecular aggregation
Single stranded DNA
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Summary:This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a “molecular pegboard”. We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations.
Bibliography:ark:/67375/TPS-2M4BVDBF-7
istex:B99BFAB155BAC8E87A7E2257F0C4111CB2C66529
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0568446