A New Approach for the Synthesis of Hyperbranched N‑Glycan Core Structures from Locust Bean Gum

A novel protocol for the synthesis of general N-glycan core structures was established by means of Manβ(1→4)Man peracetate derived from a naturally abundant locust bean gum as a key starting material. Phenyl (2-O-benzyl-4,6-O-benzylidine-β-d-mannopyranosyl)-(1→4)-3,6-di-O-benzyl-2-azido-2-deoxy-1-th...

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Bibliographic Details
Published inOrganic letters Vol. 15; no. 24; pp. 6278 - 6281
Main Authors Kumar H. V, Ravi, Naruchi, Kentaro, Miyoshi, Risho, Hinou, Hiroshi, Nishimura, Shin-Ichiro
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 20.12.2013
Amer Chemical Soc
Subjects
Carbohydrate Conformation
Chemistry
Chemistry, Organic
Galactans - chemistry
Mannans - chemistry
Molecular Sequence Data
Physical Sciences
Plant Gums - chemistry
Polysaccharides - chemical synthesis
Polysaccharides - chemistry
Science & Technology
ANTIBODIES
BETA-MANNOPYRANOSIDES
TRISACCHARIDE SEQUENCE
OLIGOSACCHARIDES
1,6-ANHYDRO-BETA-LACTOSE
EFFICIENT SYNTHESIS
GLYCOSYLATION
GLYCOMICS
DERIVATIVES
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Summary:A novel protocol for the synthesis of general N-glycan core structures was established by means of Manβ(1→4)Man peracetate derived from a naturally abundant locust bean gum as a key starting material. Phenyl (2-O-benzyl-4,6-O-benzylidine-β-d-mannopyranosyl)-(1→4)-3,6-di-O-benzyl-2-azido-2-deoxy-1-thio-β-d-glucopyranoside facilitated the synthesis of key intermediates leading to hyperbranched N-glycan core structures.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol403140h