Schinalactone A, a New Cytotoxic Triterpenoid from Schisandra sphenanthera

• Published in: Organic letters Vol. 12; no. 6; pp. 1208 - 1211
• Main Authors: He, Fei, Pu, Jian-Xin, Huang, Sheng-Xiong, Wang, Yuan-Yuan, Xiao, Wei-Lie, Li, Li-Mei, Liu, Jing-Ping, Zhang, Hai-Bo, Li, Yan, Sun, Han-Dong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 19.03.2010; Amer Chemical Soc
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry; Chemistry, Organic; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Conformation; Physical Sciences; Plant Roots - chemistry; Plant Stems - chemistry; Schisandra - chemistry; Science & Technology; Stereoisomerism; Structure-Activity Relationship; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; LANCIFOLIA; NORTRITERPENOIDS; ANTI-HIV ACTIVITY; CHINENSIS; RING; MICRANDILACTONE-A; UNIQUE SKELETON; EFFICIENT SYNTHESIS; PSEUDOLARIX-KAEMPFERI
• ISSN: 1523-7060; 1523-7052
• DOI: 10.1021/ol902974j

A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC50 values of 5.9 and 4.1 μM, respectively. A plausible biosynthetic pathway of 1 was also postulated.