Characterization of Dimeric Chiral Lithium Amide Structures Derived from N-isopropyl-O- triisopropylsilyl Valinol

The dimeric structure is characterized for a chiral amide base complex consisting of an (S)-N-isopropyl-O-triisopropylsilyl valinol ligand and lithium. The complex is characterized by a variety of NMR techniques, including multinuclear one- and two-dimensional NMR experiments and diffusion-ordered N...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 133; no. 17; pp. 6596 - 6602
Main Authors Kagan, Gerald, Li, Weibin, Li, Deyu, Hopson, Russell, Williard, Paul G
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 04.05.2011
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Summary:The dimeric structure is characterized for a chiral amide base complex consisting of an (S)-N-isopropyl-O-triisopropylsilyl valinol ligand and lithium. The complex is characterized by a variety of NMR techniques, including multinuclear one- and two-dimensional NMR experiments and diffusion-ordered NMR spectroscopy (DOSY) as well as diffusion coefficient-formula weight (D-fw) correlation analyses. Spartan calculations are presented which support the structural assignment. This structural characterization leads to an explanation of the behavior and the reactivity of these complexes in solution.
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja109041z