Polymer-Supported Pentaethylene Glycol as a Facile Heterogeneous Catalyst for Nucleophilic Fluorination

Polymer-supported pentaethylene glycols (PSpentaEG) as promising catalysts for nucleophilic fluorination with alkali metal fluoride (MF) could significantly enhance the nucleophilicity of MF and provide simple purification and recycling in the reaction. Furthermore, by their synergistic effect, the...

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Published inOrganic letters Vol. 12; no. 17; pp. 3740 - 3743
Main Authors Jadhav, Vinod H, Jang, Seung Ho, Jeong, Hwan-Jeong, Lim, Seok Tae, Sohn, Myung-Hee, Chi, Dae Yoon, Kim, Dong Wook
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 03.09.2010
Amer Chemical Soc
Subjects
Catalysis
Chemistry
Chemistry, Organic
Combinatorial Chemistry Techniques
Glycols - chemistry
Halogenation
Molecular Structure
Physical Sciences
Polymers - chemistry
Science & Technology
IMPROVED SELECTIVITY
REAGENTS
IONIC LIQUIDS
FLUORIDE SOURCE
PET
SIGNIFICANTLY ENHANCED REACTIVITY
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Summary:Polymer-supported pentaethylene glycols (PSpentaEG) as promising catalysts for nucleophilic fluorination with alkali metal fluoride (MF) could significantly enhance the nucleophilicity of MF and provide simple purification and recycling in the reaction. Furthermore, by their synergistic effect, the combination of PSpentaEG and a tert-alcohol media system showed tremendous efficiency in the fluorination of base-sensitive substrates such as sec-alkyl halide.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol101485n