Termitomycamides A to E, Fatty Acid Amides Isolated from the Mushroom Termitomyces titanicus, Suppress Endoplasmic Reticulum Stress
Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1−5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum str...
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| Published in | Organic letters Vol. 12; no. 21; pp. 5012 - 5015 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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WASHINGTON
American Chemical Society
05.11.2010
Amer Chemical Soc |
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| Abstract | Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1−5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum stress-dependent cell death. |
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| AbstractList | Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1-5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum stress-dependent cell death. Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1−5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum stress-dependent cell death. |
| Author | Kawagishi, Hirokazu Kawade, Mitsuo Nagai, Kaoru Harada, Etsuko Choi, Jae-Hoon Maeda, Kohei Hirai, Hirofumi |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20936815$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.tet.2008.10.068 10.1016/j.bmc.2008.09.044 10.1038/sj.cdd.4401778 10.1271/bbb.90279 10.1016/j.jnutbio.2005.09.007 10.1021/jm900324e 10.1111/j.1742-4658.2007.05639.x 10.1038/85463 10.1016/S0269-915X(87)80080-0 10.1073/pnas.76.2.791 10.1016/S0021-9258(18)50406-3 10.1038/70265 |
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| References | Ueda, K (WOS:000269363300040) 2009; 73 Nagai, K (WOS:000239573600004) 2006; 17 PIEARCE G D (BCI:BCI198834023553) 1987; 21 MAHONEY, WC (WOS:A1979HE51600064) 1979; 254 Katayama, T (WOS:000084136100015) 1999; 1 Choi, J (WOS:000262033000027) 2009; 65 Yoshida, H (WOS:000243562700006) 2007; 274 Wyffels, L (WOS:000268661600008) 2009; 52 Ueda, K (WOS:000260134400009) 2008; 16 OLDEN, K (WOS:A1979GL33900053) 1979; 76 Lindholm, D (WOS:000235360800005) 2006; 13 Tamatani, M (WOS:000167380400037) 2001; 7 Lindholm D. (ref1/cit1) 2006; 13 Yoshida H. (ref4/cit4) 2007; 274 Ueda K. (ref7/cit7) 2008; 16 Piearce G. D. (ref9/cit9) 1987; 1 Ueda K. (ref6/cit6) 2009; 73 Choi J.-H. (ref8/cit8) 2009; 65 Mahoney W. C. (ref11/cit11) 1979; 254 Olden K. (ref12/cit12) 1979; 76 Katayama T. (ref2/cit2) 1999; 1 Tamatani M. (ref3/cit3) 2001; 7 Wyffels L. (ref10/cit10) 2009; 52 Nagai K. (ref5/cit5) 2006; 17 |
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| Snippet | Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1−5 were... Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1-5 were... |
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| SubjectTerms | Animals Cell Death - drug effects Cell Line, Tumor Chemistry Chemistry, Organic Endoplasmic Reticulum - drug effects Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - isolation & purification Fatty Acids, Unsaturated - pharmacology Mice Molecular Structure Physical Sciences Science & Technology Stress, Physiological - drug effects Termitomyces - chemistry |
| Title | Termitomycamides A to E, Fatty Acid Amides Isolated from the Mushroom Termitomyces titanicus, Suppress Endoplasmic Reticulum Stress |
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