Termitomycamides A to E, Fatty Acid Amides Isolated from the Mushroom Termitomyces titanicus, Suppress Endoplasmic Reticulum Stress

Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1−5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum str...

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Published inOrganic letters Vol. 12; no. 21; pp. 5012 - 5015
Main Authors Choi, Jae-Hoon, Maeda, Kohei, Nagai, Kaoru, Harada, Etsuko, Kawade, Mitsuo, Hirai, Hirofumi, Kawagishi, Hirokazu
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.11.2010
Amer Chemical Soc
Subjects
Animals
Cell Death - drug effects
Cell Line, Tumor
Chemistry
Chemistry, Organic
Endoplasmic Reticulum - drug effects
Fatty Acids, Unsaturated - chemistry
Fatty Acids, Unsaturated - isolation & purification
Fatty Acids, Unsaturated - pharmacology
Mice
Molecular Structure
Physical Sciences
Science & Technology
Stress, Physiological - drug effects
Termitomyces - chemistry
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Summary:Five fatty acid amides, termitomycamides A to E (1 to 5), were isolated from the giant edible mushroom Termitomyces titanicus. The structures of 1−5 were determined by the interpretation of spectral data and/or synthesis. Compounds 2 and 5 showed protective activity against endoplasmic reticulum stress-dependent cell death.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102186p